Naltrexone and Alcohol – What Is Pharmacological Extinction?

naltrexone and alcohol

The purpose of this article is to shed light on the relationship between naltrexone and alcohol, including the concept of pharmacological extinction.

We will also cover how to use naltrexone for alcohol addiction, including the pharmacology of naltrexone, research studies, and alternatives to naltrexone.

Overview of Naltrexone and Alcohol

Naltrexone hydrochloride is a medication that has been approved to treat opioid addiction for decades, and alcohol addiction since 1994. Naltrexone is the generic name for this drug, and brands include an oral pill called Revia and a long-acting shot called Vivitrol.

Naltrexone is a opioid antagonist, meaning that it plugs the same brain receptors as opiates and endorphins (the brain’s natural pleasure chemicals). Instead of producing pleasurable effects, naltrexone sits in the receptor site and simply blocks pleasure chemicals from entering.

Specifically, naltrexone plugs the mu-opioid beta-receptor. You can see how this works in the picture below, which portrays the action of the Vivitrol shot.

naltrexone and alcohol

When alcohol is consumed, the brain releases endorphins, which are endogenous opioids that are also released in response to exercise, food, sex, and other pleasurable activities.

Naltrexone therefore prevents drinkers from feeling pleasure when they drink. When the oral pill version is consumed, it must be taken before every drinking session to be effective.

Naltrexone was approved for alcohol addiction in 1994 after studies demonstrated that it reduced the amount of alcohol consumed and the severity of relapses.

Importantly, naltrexone taken alone with abstinence shows only a small reduction in relapse rates. The mechanism through which naltrexone works requires naltrexone and alcohol to both be present, over the course of repeated episodes of drinking. This process is called pharmacological extinction.

Pharmacological Extinction

In other articles, we’ve partially explained alcohol addiction as an attempt to maintain comfortable levels of GABA, which is the brain’s primary calming neurotransmitter.

Yet as any heavy drinker knows, the calming effect of alcohol is only half of the equation. The other half is the profound sense of pleasure, euphoria, and reward that our brains come to associate with drinking.

naltrexone and alcohol

For people who are actively addicted to alcohol, nothing releases endorphins as intensely as large quantities of alcohol.

In the past few decades, scientists have concluded that alcohol’s effects are mediated at least partly through the brain’s internal opioid system. This system is closely connected to the dopamine system, which is responsible for learning, motivation, and sense of reward.

From an evolutionary perspective, this makes sense: We need to remember things in our environment that give us pleasure so that we can instinctually seek them out in the future. For people with alcohol addiction, the brain’s attempts to automate goal-seeking ends up threatening survival itself.

The progression of alcoholic drinking can therefore be seen as a learned behavior even though the drinker has no conscious control over it. This kind of subconscious learning is reinforced by a chain reaction of neurotransmitters beginning with endorphins, which eventually causes the brain to release dopamine at the very idea of drinking. For an alcoholic in withdrawal, a single thought can easily begin the process of getting ready to go obtain alcohol from a store or a bar.

Pharmacological extinction is the gradual reversal of drinking as a learned behavior. It is made possible by the repeated presence of both naltrexone and alcohol, allowing the drinker to stop feeling pleasure and euphoria from the act of drinking. Over time, the drinker’s internal opiate system and dopamine system rewire so that the thought of alcohol produces a state of indifference rather than craving.

In a sense, pharmacological extinction is the alcoholic equivalent of training Pavlov’s dogs to associate the bell with no food at all (i.e., no salivation or cravings).

naltrexone and alcohol

Pharmacological extinction requires that naltrexone and alcohol are taken together for as long as the person decides to drink. In other words, for people who use naltrexone for alcohol addiction, naltrexone should be taken before each drinking session for the rest of their lives.

If they simply stop taking it and continue to drink, endorphins will be released that could rekindle their alcohol addiction all over again.

Research Studies

naltrexone and alcohol

Over the past few decades, a lot of research has been done on naltrexone and alcohol. The use of naltrexone for alcohol disorders is well-established in the scientific literature:

  • In a 6 month double-blind, placebo-controlled study with 118 alcoholics, naltrexone was associated with significantly fewer heavy drinking days than the placebo (source)
  • A 1997 study found that when naltrexone was combined with therapy, only 35% relapsed, compared to the treatment industry standard of up to 90% relapse (source)
  • Out of 14 clinical trials conducted through 2001, only two failed to demonstrate the efficacy of naltrexone for alcohol disorders (source)
  • A 2014 meta-analysis found that naltrexone for alcohol disorders is effective at reducing heavy drinking and extinguishing cravings (source)
  • People with a particular variant of a gene (A118G Asn40Asp, or asparagine-to-aspartate amino acid substitution at position 40) for the mu opioid receptor obtain a greater high from alcohol and more dopamine response. A study conducted on alcoholics with this genotype found more success using naltrexone for alcohol addiction (in the form of reduced return to heavy drinking) than with other genotypes. (source)

The last study points to a recurring theme on this site: Due to biochemical individuality, some treatment methods work better for some people than for others.

How To Use Naltrexone For Alcohol Addiction

naltrexone and alcohol

The following information may be useful if you are considering taking naltrexone for alcohol addiction:

  • Naltrexone is a generic drug, and the two main brand names are Revia and Depade.
  • Revia comes in bottles of 30 or 100 tablets, 50 mg each, while Depade comes in bottles of 30 or 100, either 25, 50, or 100 mg each.
  • Typical dosage of naltrexone for alcohol addiction is 25-50 mg per day, either once per day, in split doses, or just prior to drinking.
  • For long term users of naltrexone for alcohol addiction, the drug only needs to be taken prior to drinking.
  • Naltrexone has a low incidence of adverse effects that force people to stop using the drug; however, side effects can occur.
  • Only take naltrexone under the supervision of a doctor.

Note: In severe cases as defined by high alcohol consumption, detoxification with medications may be necessary before introducing naltrexone for alcohol addiction and attempting to achieve pharmacological extinction. Usually, 3-7 days of abstinence are recommended before treatment with naltrexone. (source)

Before taking naltrexone for alcohol addiction, make sure to review the following:

Alternative Treatment Methods

naltrexone and alcohol

Not everyone can obtain naltrexone, since it must be prescribed by a doctor. Fortunately, more doctors are becoming aware of the relationship between naltrexone and alcohol.

While naltrexone for alcohol addiction is a unique form of harm reduction, there are alternatives – including drugs that have been shown to be effective in controlling alcohol cravings when administered for long periods of time.


Baclofen is a prescription drug that is structurally similar to GABA. Baclofen can be used to manage alcohol withdrawal symptoms, and it has also been used long-term by a growing number of people to achieve a state of indifference toward alcohol.

To learn more, check out on the interesting baclofen alcohol relationship.


Gabapentin is similar to baclofen in that it helps the brain produce more GABA. It is increasingly popular for alcohol withdrawal, and sometimes combined with baclofen for long-term extinguishing of alcohol cravings.

You can read more about gabapentin in this article on this treatment method.


Naltrexone for alcohol addiction is a little-known but highly effective treatment that our medical establishment has all but hidden from patients. While not everyone responds well to naltrexone, greater awareness of the relationship between naltrexone and alcohol can improve recovery odds for many people.

There is no one-size-fits-all approach for alcohol detox and recovery. Most people who quit drinking are not enlightened about other pharmacological options, nutrient repair, the hypoglycemic trap that so many people fall into, or holistic strategies for improving quality of life.

Check Fit Recovery’s list of supplements that work best for supporting the brain-body system through alcohol recovery.

If you have any questions about naltrexone and alcohol, or pharmacological extinction, please leave them in the comment box below.


Dr. Ken Starr is board certified in both Addiction Medicine and Emergency Medicine, and diplomate of the American Board of Addiction Medicine. In addition to his work as the Addiction Medicine Director for Fit Recovery, he operates Ken Starr MD Wellness Group in Arroyo Grande, CA. His clinic offers advanced drug and alcohol detox methods, long term recovery facilitation, and IV nutritional programs including NAD+ therapy.

Hierarchy of Alcohol Recovery


  • Ken Starr, M.D., FACEP

    Dr. Ken Starr is board certified in both Addiction Medicine and Emergency Medicine, and diplomate of the American Board of Addiction Medicine. In addition to his work as the Addiction Medicine Director for Fit Recovery, he operates Ken Starr MD Wellness Group in Arroyo Grande, CA. His clinic offers advanced drug and alcohol detox methods, long term recovery facilitation, and IV nutritional programs including NAD+ therapy.

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The information we provide while responding to comments is not intended to provide and does not constitute medical, legal, or other professional advice. The responses to comments on are designed to support, not replace, medical or psychiatric treatment. Please seek professional care if you believe you may have a condition.

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[…] Prescription-only drugs that have been FDA-approved for alcohol-use disorder (AUD) include naltrexone, acamprosate, and […]

4 years ago

Incredible article!!!

Chris Scott
4 years ago
Reply to  Chelssa

Thanks Chelssa!

sondra roberts
sondra roberts
5 years ago

I live in Nashville Tn and can not find anybody to help me with the Sinclair solution. I even email a rehab in Knoxville that says they use the Sinclair method and they never got back to me.

Chris Scott
5 years ago
Reply to  sondra roberts

Hi Sondra, the C Three Foundation provides a resource for finding doctors familiar with Sinclair:



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